https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Genome-wide association study identifies five new schizophrenia loci https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14264 −11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10−9), ANK3 (rs10994359, P = 2.5 × 10−8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10−9).]]> Wed 11 Apr 2018 18:45:05 AEST ]]> Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24896 Wed 11 Apr 2018 10:56:49 AEST ]]> Sifting the wheat from the chaff: prioritizing GWAS results by identifying consistency across analytical methods https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12709 Sat 24 Mar 2018 08:16:20 AEDT ]]>